105 CMR, § 720.200
MASSACHUSETTS
LIST OF
INTERCHANGEABLE DRUGS
Department of Public Health regulation 105 CMR 720.050 describes the Massachusetts List of Interchangeable Drugs.
105 CMR 720.050(a) calls for the automatic adoption of all "A" rated drug products listed in the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements as published by the U.S. Food and Drug Administration (FDA), Department of Health and Human Services. This publication is commonly referred to as the "Orange Book". It is reprinted by the U.S. Pharmacopeial Convention Inc. (USP) as Volume III of the USP DI.
105 CMR 720.050(b) allows for the establishment of the Massachusetts Additional List of Interchangeable Drugs (Additional List), and provides the criteria upon which these drug products are approved.
All prescriptions written by generic name can be interchanged if the drug is multi-source. To determine if a prescription written for a brand name drug product is interchangeable in Massachusetts:
Copies of the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements ("Orange Book") are available from the:
U.S. Food and Drug Administration
Department of Health and Human Services
Government Printing Office
Washington, D.C. 20402-9371
OPC 6768
(202) 783-3238
Copies of the USP DI (third volume of USP DI is the "Orange Book") are available from:
The United States Pharmacopeial Convention, Inc.,
12601 Twinbrook Parkway
Rockville, MD 20852
(301) 881-0666
Copies of the Massachusetts Additional List of Interchangeable Drug Products (document number 105 CMR 720.000) are available from:
The State House Bookstore Room 116
Boston, MA 02133
(617) 727-2834
and www.magnet.state.ma.us/dph/dcp/Drug Formulary/Drug Interchange
TABLE OF CONTENTS
Foreword
Introduction
Drug Product Problem Reporting Instructions
Exception List
Format of the Additional List
NDA, ANDA, Applicant (name) Changes
Abbreviations
Massachusetts Additional List of Interchangeable Drugs (Alphabetical list of Official (Generic) Drug Names)
Parti al Proprietary Brand Cross-reference
FOREWORD
The Massachusetts List of Interchangeable Drugs, is prepared by the Drug Formulary Commission (DFC) and the Department of Public Health. The DFC is comprised of nine men and women appointed by the Governor for the express purpose of developing a list of those drug products that are safely interchangeable -- that is, equivalent to each other in all significant respects. The DFC was established by M.G.L. c. 17, § 13. This law was enacted with the intent of saving money for consumers ofprescription drugs, since drug products that are marketed under trademark or proprietary names are often available in the generic forms from competing manufacturers at substantially lower prices. M.G.L. c. 112, § 12D mandates prescription forms that allow practitioners to prescribe interchangeable drug products by simply signing the signature line. If a practitioner determines that a brand name drug product should be dispensed, he/she must sign the signature line and write the words "no substitution" in his/her own handwriting in the space provided below the signature line.
The regulations call for the automatic adoptionof "A"rated drugproducts listed in the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements (commonly referred to as the "Orange Book") as published by the U.S. Food and Drug Administration, Department of Healthand Human Services, plus a list of additional drug products, the Massachusetts Additional List of Interchangeable Drugs ("Additional List"), individually reviewed and approved by the DFC and the Department. The regulations provide the criteria upon which the drug products listed on the Additional List are approved for interchange. The regulations also provide the DFC and the Department with the authority to review any "A" rated drug product listed in the "Orange Book" or drug product approved for interchange on the Additional List and delete it from the list of interchangeable drug products if deemed appropriate. Drug products assigned an "A" rating by FDA which are deleted from the Massachusetts List are placed on the Exception List. Drug products listed on the Additional List which are subsequently deleted are removed from the Additional List.
Of the many factors considered by the Commission in determining which drugs to include on the List, equivalent safety and effectiveness are paramount. The Commission reviews evidence on bioequivalence and pharmaceutical equivalence and includes on the List only those drug products determined to be fully interchangeable and whose manufacturers are approved by the U.S. Food and Drug Administration. Practitioners may prescribe any drug that appears on the List with confidence that it is as safe and effective as its brand name counterpart.
The efforts of the Commission in the assessment and evaluation ofdata and the preparationofthe List are to be commended. The Department presents the Massachusetts List of Interchangeable Drugs with pride and with confidence that the List will greatly benefit consumers throughout the Commonwealth.
INTRODUCTION
INTERCHANGEABLE (GENERIC) DRUG LAW
In 1976 the Massachusetts Legislature passed an Act Further Regulating the Establishment of a Formulary of Interchangeable Drug Products (St. 1976, c. 470, § 13), commonly known as the Generic Drug Law. This law, enacted to promote and regulate the use of generic drugs, created the Drug Formulary Commission to develop a list of interchangeable drug products and also required the use of a standard prescription form to encourage practitioners to prescribe generic drugs.
PRESCRIPTION FORM
M.G.L. c. 112, § 12D mandates prescription forms with one signature line. Ifthe prescriber signs the prescription form and writes the words "no substitution" in his/her own handwriting in the space provided below the signature line, the pharmacist must fill the prescription exactly as indicated, with no interchange permitted. However, if the prescriber signs the prescription and does not write "no substitution" under his/her signature, the pharmacist is legally required to dispense a less expensive, equivalent interchangeable drug product listed in the Massachusetts List of Interchangeable Drugs if one is reasonably available.
MASSACHUSETTS LIST OF INTERCHANGEABLE DRUGS
The Massachusetts List of Interchangeable Drugs (MLID) consists of the "A" rated drug products listed in the "Approved Drug Products with Therapeutic Equivalence Evaluations" and its supplements as published by the U.S. Food and Drug Administration, Department of Health and Human Services ("Orange Book") and the Massachusetts Additional List of Interchangeable Drugs (Additional List). The Additional List is developed by the Drug Formulary Commission. The Commission determines drug products to be interchangeable only when they meet certain criteria:
The Commission judges that all the drugs included on the MLID meet these standards and are bioequivalent, if essential, based on assessment and evaluation of the U.S. Pharmacopeia and its supplements, other state and hospital formularies, listings of the U.S. Department of Health and Human Services of the FDA, and on the expertise of its members.
The List does not include:
Bioequivalence is determined to be necessary for a particular drug when bioinequivalence might result in therapeutic failure or hazard to the patient. Bioequivalent drug products do not show a significant difference in the rate and extent of absorption when administered at the same dosage under similar conditions. Drugs that are equivalent in the extent to which they are absorbed into a patient's body that differ in the rate of absorption may be therapeutically equivalent -- having the same medical effect -- either because the rate of absorption is not essential to the attainment of effective body concentrations of the drug, or because the difference in the rate is otherwise considered medically insignificant. Bioequivalence is a primary consideration for those drug products with a narrow therapeutic/toxic dosage range (when variation in the rate orextent of absorption could have a critical effect) where careful determination of the correct dosage and monitoring of the patient is essential to safe and effective use. To determine for which drugs bioequivalence is essential, the Commission relies on expert medical testimony, studies done by the pharmaceutical industry, the knowledge and expertise of the individual members of the Commission, and advice from the FDA.
All drug products manufactured by FDA approved firms are considered safe and effective for their intended use, even if the product has not been included in the MLID. A practitioner may begin a patient's therapy with a drug product from any manufacturer who has been approved by the FDA, even though interchange of the drug once the dosage has been calculated for the individual is not advised.
Several generic drug products are manufactured under the same new drug application (NDA) as the brand name drug products. According to section 1.6 of the Orange Book, drug products with the same NDA are therapeutically equivalent. Massachusetts regulations allow the interchange of these products. Distributors or repackagers of drug products manufactured under the same NDA as the brand name product are not identified in the Orange Book. Pharmacists who may not be able to determine if drug products are interchangeable should contact the manufacturers, distributors or repackagers. In addition the Department maintains an unofficial list of these products.
Information relative to the Interchangeable (Generic) Drug Law may be obtained from the Department of Public Health, Division of Food and Drugs, 305 South Street, Jamaica Plain, MA 02130, telephone number (617) 727-2670, and from the Boards of Registration in Medicine, Dentistry and Pharmacy.
DRUG PRODUCT PROBLEM REPORTING INSTRUCTIONS
Since 1971 the United States Pharmacopeia (USP), in cooperation with various professional associations and the Food and Drug Administration (FDA), has operated the Drug Product Problem Reporting Program. This program can be utilized by pharmacists, physicians, or consumers to report any product problems encountered when using drugs interchanged under the Massachusetts generic drug law. The program is product oriented, and patient identification not requested. Should you prefer to remain anonymous, so indicate to the USP and your name will be withheld from the manufacturer and the FDA. Your participation in reporting problems will help to ensure that the drug products prescribed and dispensed in Massachusetts are of continued high quality.
Reports should be sent to The United States Pharmacopeial Convention, Inc., 12601 Twinbrook Parkway, Rockville, MD 20852, (301) 881-0666. The USP is an impartial, non-governmental organization concerned with drug standards and quality control. After USP receives a report, copies are forwarded to the FDA and to the manufacturer of the product involved. Either the FDA or the manufacturer may act to investigate or correct problems.
EXCEPTION LIST
Orange Book "A" rated drug products not approved for interchange.
There are currently no products designated to be listed on the Exception List.
ADDITIONAL LIST
The Massachusetts Additional List of Interchangeable Drugs (Additional List) has been printed in a format designed to be concise and understandable. Interchangeable drugs are listed alphabetically according to their official (chemical or generic) names, and separate sections in each listing show dosage forms, strengths, FDA approved manufacturers, and categories.
DRUG
Drugs are listed in alphabetical order by their generic names and are printed in capital letters. Drug products containing more than one active ingredient (for example, CODEINE PHOSPHATE, GUAIFENESIN) are listed in the conventional order of ingredients.
Only drug products grouped under single headings are to be interchanged.
DOSAGE FORM
Under the generic names are listed the various multisource dosage forms in which a drug product is available. Abbreviations used for dosage forms and approved manufacturers are found in the front of the Additional List.
Only identical dosage forms and strengths of identical drugs are to be interchanged.
STRENGTH
The approved strengths of the drug products are listed under the heading "Strength(s)." The "strengths" must be read along with the "dosage forms" since any strength shown is available only for the dosage form directly to its left. Dosage strength is in metric units that are sometimes rounded off from apothecary measures, which may introduce slight variations in the strength of certain products. Single ingredient drug product strengths are separated by commas. Combination drug products have a slash separating the strengths of the individual ingredients. If more than one strength of a single component of a combination drug product is approved, they will be separated by commas. For example, the strength of a tablet of aspirin with codeine phosphate is "325mg / 15mg, 30mg, 60mg" which means that the combination is available with 325 milligrams of aspirin and 15, 30, or 60 milligrams of codeine phosphate. Drug products with three or more components have their active ingredients listed individually in parentheses and have slashes separating the strengths of the individual ingredients.
MANUFACTURERS
Next to the heading "Manufacturers" are all approved manufacturers for the drug product in that group, listed by three letter abbreviations in capital letters. (See list of manufacturer abbreviations in front of the Additional List.) Listed manufacturers have met all legal requirements, including compliance with the FDA Good Manufacturing Practices for the production of the drug product indicated. Approved manufacturers hold current new drug applications (NDAs) or abbreviated new drug applications (ANDAs) when required by law.
NDA, ANDA APPLICANT (NAME) CHANGES
Because it is not practical to identify in the Massachusetts Additional List of Interchangeable Drugs (Additional List) each and every product involved when an applicant transfers its entire line of approved drug products to another applicant, or when an applicant changes its name, these transfers and name changes are identified in this section. In addition, the new manufacturers are listed in parenthesis beside the original manufacturer under the Manufacturers' Abbreviations section of the Additional List. Where only partial approved product lines are transferred between applicants, each approved product involved will appear with the manufacturer name change in the Additional List amendment.
Previously listed name changes have been incorporated into the revised Manufacturers' Abbreviations section.
ABBREVIATIONS
The following abbreviations are used in the Massachusetts List of Interchangeable Drugs.
DOSAGE FORMS
aero | aerosol |
amp | ampule |
cap | capsule |
conc | concentrate |
e.c. | enteric-coated |
elix | elixir |
g | gram |
Hbr | hydrobromide |
HCl | hydrochloride |
HC | hydrocortisone |
inhl | inhalation |
inhl liquid | inhalation liquid |
inhl sol | inhalation solution |
inj | injection |
irr sol | irrigating solution |
I.U. | international units |
liq | liquid |
lot | lotion |
mcg | microgram |
mEq | milliequivalents |
mg | milligram |
ml | milliliter |
oint | ointment |
ophth | ophthalmic |
oral gran | oral granules for |
reconstitution | |
oral powder | oral powder for |
reconstitution | |
oral sol | oral solution |
pow | powder |
sol | solution |
SR | sustained release |
subl tab | sublingual tablet |
supp | suppository |
susp | suspension |
syr | syrup |
tab | tablet |
top aero | topical aerosol |
top swab | topical swab |
U | units |
vag | vaginal |
MANUFACTURERS' ABBREVIATIONS
3MP | 3M Pharmaceutical |
AAA | Alpha Therapeutic |
ABB | Abbott |
ABI | Abic |
ABL | Able Laboratories |
ACI | ACIC Limited |
ACP | Advanced Care Prod. |
ADV | Advanced Remedies |
AGV | Agvar Chemicals |
AKO | Akorn |
AKZ | Akzona Inc. |
ALC | Alcon Labs |
ALL | Allergan Pharmaceuticals |
ALI | Alliance Pharmaceutical |
ALP | Alpharma |
APP | Alphapharm Party |
ALT | Altana |
ALZ | Alza Corp. |
ALR | Alra Laboratories |
AMA | Amaric |
AMB | Ambix Labs |
ACC | American Cyanamid Co. |
AHP | American Home Products |
ARL | American Regent Labs. |
AME | Amersham |
AMG | Amgen |
AMI | Amide Pharmaceuticals |
AMT | American Therapeutics |
ANA | Anabolic |
ANB | Anbex |
ANC | Angus Chemical |
ANE | Anesta |
ANG | Angelini |
APO | Apothecon |
APK | Apothekernes |
APP | American Pharmaceutical Partners |
Inc | |
ARC | Arcola Labs. |
APC | Arcum Pharmaceuticlal Corp. |
ARP | Armenpharm |
ARM | Armour Pharmaceuticals |
ASC | Ascot Hospital Products |
ASA | Asta |
ASP | Astra Pharmaceuticals LP |
ATH | Athena Neurosciences |
BAK | Baker Norton |
BAN | Banner Pharmacaps |
BAP | Barlan Pharmacal |
B/I | Boehringer Ingelheim |
B/M | Boehringer Mannheim. Ther. Div |
BAR | Barr Labs |
BAS | Basel Pharmaceuticals |
BAT | Bartor |
B&L | Bausch & Lomb |
BAY | Bayer Corp |
BEA | Beach Prod. |
B-D | Becton,Dickinson & Co. |
BED | Bedford Laboratories |
BEL | Bell |
BDP | Beta Derm Pharmaceuticals |
BER | Berlex |
BFA | B.F. Asher |
BHC | B.H. Chemicals |
BID | Biodevelopment |
BIO | Bio Technology General |
BIV | Biovail |
BLA | Blairex Laboratories |
BLO | Block Drug Co. |
BLU | Bluline |
BRL | Blue Ridge Laboratories |
BOC | Bock Pharmacal |
BOW | Bowman Pharm. |
BMS | Bristol Myers Squibb |
BRC | Bracco Diagnostics |
BRD | Bradley Pharm. |
BRA | Braintree Laboratories |
BRI | Bristol-Myers Prod. |
BTG | BTG Pharmaceuticals |
BVL | Ben-Venue Labs |
BYR | Byron Chemical |
C&M | C & M Pharmacal |
CAD | Cadema Medical Products |
CAG | Calgon Corp. |
CDC | Carderm Capital |
C-P | Chesebrough - Ponds |
C-W | Cook - Waite |
C/C | Chase Chemical |
CSL | Chase Laboratories |
C/P | Corvit Pharmaceuticals |
CAL | Carlisle |
CAM | Camall |
CAR | Carnick Labs |
CTW | CarterWallace |
CEN | Century Pharmaceuticals |
CBV | Cetus Ben Venue Therapeutics |
CHA | Chamberlin Parenteral Corp. |
CHE | Chelsea Laboratories |
CHM | Chemed Corp. |
CVO | Ciba Vision Ophthalmics |
CIR | Circa Pharmaceuticals |
CJD | Copanos, J.D. |
CLA | Clay - Park |
CLO | Clonmel Healthcare |
CMB | C.M. Bundy |
CMC | Consolidated Midland Corp. |
C/T | Controlled Therapeutics |
CMP | Carolina Medical Products |
CNC | H.R. Cenci |
COL | Colgate Palmolive |
COM | Combe |
CON | Connaught Laboratories |
COO | Cooper Labs |
COP | Copley Pharmaceutical |
CPG | Consolidated Pharmacy Group |
CRE | Creighton Products |
CUM | Cumberland Swan |
CUR | Curatex Pharmaceuticals |
CTL | Central Pharmacal |
D&G | Davis & Geck |
D/L | DPT Laboratories |
D-R | Del-Ray Laboratories Inc. |
DAN | Danbury Pharmacal |
DAR | Darby Group Companies |
DEL | Dell |
DEP | Deproco |
DER | Dermik Laboratories |
DES | Deseret Medical |
DEY | Deylabs |
DHL | DHL Laboratories |
DIA | Dial Corp. |
DIS | Dista |
DMD | Duramed |
DMG | D M Graham Laboratories |
DOW | Dow Pharmaceutical |
DPT | Dupont Pharmaceuticals |
DPM | Dupont Merck |
DUR | Dura Pharmaceuticals |
DUN | Dunhall |
DYN | Dynapharm |
E/K | Eastman Kodak |
EAT | Eaton Medical Corp. |
ECR | ECR Pharmaceuticals |
ELA | Elan Pharmaceuticals |
ELL | Ellis Pharmaceuticals |
EMP | EM Pharma |
END | Endo |
EON | Eon Laboratories |
ENQ | Enquay Pharm |
ENZ | Enzon |
ESR | Elkins-Sinn/AH Robins |
ERS | Ersana |
ESI | ESI Lederle Generics |
ESP | ESI Pharmacal |
ETH | Ethicon Inc. |
ETX | Ethex |
ETK | Ethitek Pharmaceuticals |
EVY | Everylife |
EZC | E Z EM Co. |
FAU | Faulding Pharm. Co. |
FER | Ferndale |
FRT | Ferrante |
FRR | Ferring Labs |
FIS | Fisons |
FLE | Fleming & Co. |
FOR | Forest |
FOU | Fougera |
FOY | Foy |
FRE | Fresenius |
G&W | G & W |
GAL | Galderma |
GEI | Geigy |
GEC | Gencon |
GED | Genderm |
GET | Genentech |
GEP | Genpharm |
GEV | Geneva |
GES | Gensia Sicor Pharmaceuticals Inc |
GEZ | Genzyme |
GIL | Gilbert Laboratories |
GLD | Glades |
GLW | GlaxoWellcome |
GLE | Glenwood |
GLO | Global Pharm. |
G/P | Golden Pharms. |
GOL | Goldine |
GRE | Greenstone |
GRI | Griffen,KW |
G/L | Gruppo Lepetit |
GUA | Guardian |
GYM | GYMA Laboratories |
GYN | Gynopharm |
H-R | Holland-Rantos |
HAL | Halsey Labs |
HAM | Hamilton Pharmaceuticals |
HAN | Hnford GC |
HEA | Heather |
HEN | Heran Pharmaceutical |
HEX | Hexcel Chemical Products |
HER | Hermal Pharmaceutical |
HIC | Hickam |
H/D | Hill Dermaceuticals |
HIR | Hirsch Industries |
HIT | Hi Tech Pharma |
HTP | High Technology Pharmacal |
HLC | Halocarbon |
HCC | Hoechst Celanese Corp. |
HMR | Hoechst Marion Roussell |
HOE | Hoechst-Rousel |
HOR | Horus Therapeutics |
HOY | Hoyt |
HUD | Hudson Pharmaceuticals |
HUN | Huntington |
HYB | Hybritec Inc. |
HYG | Hygenics |
HYR | Hyrex |
IMM | Immunex |
IMP | IMP Inc. |
ICN | ICN Pharmaceuticals |
IMS | International Medication |
INP | Interpharm |
INV | Invamed, Inc. |
INW | Inwood Labs |
ICC | Interchem Corp. |
ILC | International Latex Corp. |
ING | Ingram Pharmaceutical |
INH | Inhalon |
IOL | Iolab |
IOM | Iomed |
IPR | IPR Pharm |
IVA | IVAX |
J&J | Johnson & Johnson |
JAC | Jacobus |
JAN | Janssen Pharmaceuticals |
JER | Jerome Stevens Labs |
JRW | Johnson RW |
JON | Jones Pharma Inc |
KAL | Kalapharm |
KBP | Kabi Pharmacia |
KEE | Keene |
KED | Kendall |
KEN | Kenwood |
KIN | King Pharmaceuticals |
KIR | Kirkman Sales |
KNO | Knoll |
KPI | Key Pharmaceuticals |
KVP | KV Pharmaceutical Co. |
L/F | Labs Fournier |
L/A | Laboratories Atral |
LAF | Lafayette Pharms |
LAN | Lannett |
LED | Lederle |
LEI | Leiras |
LEK | Lek Ljubliana |
LEM | Lemmon |
LEO | Leo Pharms |
LIF | Life Labs |
LIL | Lilly |
LIP | Liposome |
LIQ | Liquipharm |
LNK | LNK International |
LOC | Loch Pharmaceuticals |
LOR | Lorex |
LOT | Lotus Biochemical |
LPI | LPI Holding |
LUI | Luitpold |
LUS | Lek USA Inc. |
LYN | LYNE Laboratories |
M/P | Mallinckrodt Pharmaceutical. |
MAY | Mayrand |
MAT | Matrix Labs |
MCG | Mcgaw |
MCN | McNeil Consumer Products |
MDP | MD Pharmaceuticals |
MEA | Mead Johnson |
MJN | Mead Johnson Nutritionals |
M/R | Medco Research |
MVA | Medeva |
MEP | Medics Pharmaceuticals |
MPI | Medi Physics, Inc. |
MAG | Mepha AG |
MER | Mericon |
MET | Metronic |
MGI | MGI Pharma |
MID | Midway Medical |
MIK | Mikart Laboratories |
MIS | Mission Pharmacol |
MJP | MJ Pharmaceuticals |
MKL | Moore Kirk Labs |
MLI | Marchar Laboratories |
MLP | Miller Pharmacal |
MLX | Milex |
MMD | Marion Merrell Dow |
MOR | Morton Grove |
MCK | Merck & Co. |
MSM | Marsam |
MSL | Marshall Pharmacal |
MTC | Martec |
MOV | Mova |
MUR | Muro |
MUT | Mutual Pharmaceuticals |
MYL | Mylan Pharmaceuticals |
NEP | Nephron Pharmaceuticals Inc |
NEU | Neutrogena |
NOR | Norbrook Laboratories |
N/W | Norton Waterford |
N/N | Novo Nordisk |
NEW | Newtron Pharmaceuticals |
NHN | Norton HN |
NOV | Novocol |
NVP | Novopharm Ltd. |
NUM | Numark |
NYC | Nycomed |
NYL | Nylos Trading |
ORI | Organon, Inc. |
OCL | Oclassen |
OHM | OHM Laboratories |
OMD | Ohmeda Pharmaceutical |
OSA | On Site Azla |
ODC | Ormont Drug & Chemical |
OPC | Ortho Pharmaceuticals |
OPT | Optopic Laboratories Corp. |
ORG | Organics |
OAP | Otsuka America Pharmaceutical |
PAK | Pal-Pak |
PAL | Palisades |
P/D | Parke Davis |
P/I | Plantex/Ikpharm |
P/K | Purepac-Kalipharma |
P/P | Parmed Pharmaceuticals |
PAC | Paco Research |
PAD | Paddock Labs |
PHD | Pharmaderm |
PAN | Panray |
PAR | Par |
PNL | Parnell |
PER | Perrigo |
PCE | Pharmachemie |
PHC | Pharmics |
PHK | Pharmakinetics Labs |
PHM | Pharmeral |
PHO | Phoenix Labs |
PHS | Pharma Serve |
PHT | Pharmaton |
PFF | Pfeiffer |
PFI | Pfizer |
P/U | Pharmacia & Upjohn |
P/A | Pharmaceutical Association |
PIO | Pioneer Pharmaceutical Inc. |
PPI | Physicians Products Inc. |
PSA | Pharmaceutical Specialist Assoc |
POH | Pohl Boskamp |
POL | Polymedia |
PGP | Prographarm |
PRD | Professional Disposables |
PRO | Proter Laboratory |
PRI | Private Formulations |
P&G | Proctor & Gamble |
PRV | Pharmavite |
PTK | Pharma-Tek |
PUF | Purdue Frederick |
PUR | Purepac |
QUA | Quantum Pharmics Ltd. |
QLT | QLT PhototherapeuticsInc. |
RAN | Ranbaxy Pharmaceuticals |
R/C | Reckitt & Colman |
R&C | Reed & Carnrick |
R/I | Research Industries |
RXP | Rexar Pharmacal |
RAC | Rachelle Labs |
REN | Ren-Pharm Internatl. Ltd. |
RHP | Rhone - Poulenc |
RPR | Rhone-Poulenc Rorer |
RAH | Robins, A.H. |
REX | Rexall/Sundown |
RIC | Richlyn Labs |
ROC | Roche Labs. |
RPF | Roerig/Pfizer |
ROA | Roaco |
RBP | Roberts Pharmaceutical |
ROR | Rorer |
ROS | Ross Labs |
ROX | Roxane Labs |
ROY | Royce Laboratories |
RPC | Rosemont Pharmaceutical Corp |
RUG | Rugby Labs |
S-M | Spencer-Mead |
S/W | Sanofi Winthrop |
S/L | Schmid Laboratories |
SAK | Sankyo |
SAV | Savage Labs/Altana |
SAN | Sandoz |
SCE | Scherer, R.P. |
SPI | Schein Pharmaceutical, Inc. |
SCH | Schering Corporation |
S/P | Schering/Plough |
SWZ | Schwarz Pharma |
SZG | SchwarzGMBH |
SCI | ScinoPharm International |
SCS | SCS Pharmaceuticals |
SEA | Searle |
SER | Serono Laboratories |
SEQ | Sequus Pharmaceuticals |
SHM | Sherwood Medical |
SHI | Shionogi USA |
SID | Sidmak Laboratories |
SIG | Sigma Tau |
SIX | Silarx |
SKB | Smith, Kline Beecham |
SBH | Sola Barnes Hind |
SOL | Solopak Laboratories |
SLV | Solvay |
SOM | Somerset |
SBM | Sorin Biomedics |
SDP | Sperti Drug Products |
STI | Steifel |
STL | Stanlabs Pharmaceutical Co. |
STR | Star Pharmaceuticals |
STS | Steris Laboratories |
STZ | Storz Ophthalmics |
SUP | Superpharm |
SPP | Suppositoria |
SUR | Survival Technology |
SYN | Syntex |
SYO | Syosset Labs |
TAB | Tablicaps |
TAG | Tag Pharmaceuticals |
TAK | Takeda |
TAP | Tap Holdings |
TAR | Taro Pharmaceutical |
TAY | Taylor Pharmaceuticals |
TEC | Technilab |
THE | Theratech |
THK | Therakos |
THA | Thames Phamacol Co. Inc. |
TIC | Tican Pharmaceuticals |
TOP | Topiderm |
T/L | Torch Laboratories |
TOR | Torigian Lab |
UDL | UDL Laboratories |
UMD | Unimed |
UPJ | Upjohn |
USL | Upsher-Smith Labs |
VAL | Vale Chemical |
VAN | Vangard |
VES | Vestal |
VIC | Vicks Pharmacy Products |
VIN | Vintage |
VIR | Viratek |
VIS | Vistakon, Inc. |
VIV | Vivan Pharmacal |
W-A | Wyeth Ayerst |
W-C | Warner-Chilcott |
WAW | Warner Wellcome |
WRR | Warrick Pharm |
WEP | WE Pharmaceuticals |
WEN | Wendt Laboratories |
WPP | West Point Pharma |
WES | Westwood Squibb Pharmaceuticals |
W-W | West-Ward |
W/L | Wharton Labs |
WBY | Whitby |
WWT | Whiteworth Towne |
WAL | Wallace Labs |
WAR | Warner-Lambert |
WAT | Watson Laboratories |
WOC | Wockhardt |
XTT | Xttrium Laboratories |
YAM | Yamanouchi |
YOS | Yoshitomi Laboratories |
ZCA | Zeneca |
ZGP | Zenith Goldline Pharmaceuticals |
MASSACHUSETTS ADDITIONAL LIST OF INTERCHANGEABLE DRUGS
PARTIAL PROPRIETARY BRAND CROSS-REFERENCE
Generically equivalent drug products in the same strength and dosage form listed in the Additional List are interchangeable if their respective manufacturers are listed for that product. This partial crossreference section does not attempt to list all brand names which are approvedforinterchange. Formost products only one, usually the innovator or most commonly prescribed brand, is listed below for quick reference purposes.
See page 4105 for precise instructions for determining the interchangeability of drug products.
BRAND SEE
(ATROPINE SULFATE, HYOSCINE HBr, HYOSCYAMINE HBr, PHENOBARBITAL)
(THEOPHYLLINE, POTASSIUM IODIDE, ALCOHOL)
ACTIFED ............................................................TRIPROLIDINE HCl, PSEUDOEPHEDRINE HCl
ANDROID..............................................................................METHYLTESTOSTERONE
ANTABUSE DISULFIRAM
AQUAMEPHYTON............................................................................. PHYTONADIONE
AURALGAN......................................................................... BENZOCAINE, ANTIPYRINE
AZO-GANTANOL.................................................... SULFAMETHOXAZOLE, PHENAZOPYRIDINE
AZO-GANTRISIN .......................................................SULFISOXAZOLE PHENAZOPYRIDINE HCl
AZULFADINE ................................................................................. SULFASALAZINE
BENADRYL ............................................................................DIPHENHYDRAMINE HCl
CYANOCOBALAMIN
BICILLIN............................................................................ PENICILLIN G BENZATHINE
BRETHINE ............................................................................. TERBUTALINE SULFATE
CHLOR-TRIMETON............................................................. CHLORPHENIRAMINE MALEATE
COL-BENEMID .................................................................... PROBENECID W/ COLCHICINE
CYCLANDELATE
DECADRON ................................................................................. DEXAMETHASONE
DESQUAM .................................................................................BENZOYL PEROXIDE
DIMETANE DX................................ BROMPHENIRAMINE, DEXTROMETHORPHAN, PSEUDOEPHEDRINE
DIUPRESS......................................................................CHLOROTHIAZIDE W/ RESERPINE
DONNATAL................................................................... ATROPINE SULFATE COMPOUND
DRAMAMINE ...............................................................................DIMENHYDRINATE
DRIXORAL.................................................................................. (product reformulated)
ECONOPRED ......................................................................... PREDNISOLONE ACETATE
ELIXOPHYLLINE KI ......................................................... THEOPHYLLINE, POTASSIUM IODIDE
EMPIRIN W/ CODEINE .........................................................ASPIRIN W/ CODEINE PHOSPHATE
ESTINYL .................................................................................. ETHINYL ESTRADIOL
EXNA. ........................................................................................ BENZTHIAZIDE
FEDAHIST............................................. PSEUDOEPHEDRINE HCl, CHLORPHENIRAMINE MALEATE
GLAUCON ....................................................................................EPINEPHRINE HCl
GRANULEX ............................................................... TRYPSIN, BALSAM PERU, CASTOR OIL
HALOTESTIN .............................................................................FLUOX\YMESTERONE
HYCOMINE..........................................HYDROCODONE BITARTRATE W/ PHENYLPROPANOLAMINE
HYDROPRES ........................................................... HYDROCHLOROTHIAZIDE W/ RESERPINE
ISOPTO CARPINE ............................................................................. PILOCARPINE HCl
ISORDIL TEMBID....................................................................... ISOSORBIDE DINITRATE
ISUPREL .................................................................................. ISOPROTERENOL HCl
KAON. ............................................................................... POTASSIUM GLUCONATE
KENALOG ....................................................................... TRIAMCINOLONE DIACETATE
LARODOPA .........................................................................................LEVODOPA
LEVSIN ............................................................................. L-HYOSCYAMINE SULFATE
LIBRAX........................................................... CHLORDIAZEPOXIDE W/CLIDINIUM BROMIDE
MANDELAMINE ..................................................................METHENAMINE MANDELATE
MEBARAL ................................................................................... MEPHOBARBITAL
MENEST ...............................................................................ESTROGENS, ESTERIFIED
METALONE T.B.A ...................................................................PREDNISOLONE TEBUTATE
MICRONASE ....................................................................................... GLYBURIDE
MAGNESIUM SALICYLATE
NEO-SYNEPHRINE ......................................................................... PHENYLEPHRINE HCl
CHLORAL HYDRATE
PAMELOR .................................................................................NORTRIPTYLINE HCl
PHENERGAN PLAIN ....................................................................... PROMETHAZINE HCl
PONTOCAINE .................................................................................TETRACAINE HCl
PROSED.................................METHENAMINE COMBINATION (METHENAMINE, PHENYLSALICYLATE,
ATROPINE SULFATE, HYOSCYAMINE, BENZOIC ACID METHYLENE BLUE)
PROSTIGMINE .................................................................NEOSTIGMINE METHYLSULFATE
PYRIDIUM ..............................................................................PHENAZOPYRIDINE HCl
QUINAMM ..................................................................................QUININE SULFATE
SALUTENSIN ............................................................... HYDROFLUMETHIAZIDE, RESERPINE
SANOREX.......................................................................................... MAZINDOL
SERAPES.............................................. HYDRALAZINE HCl, HYDROCHLOROTHIAZIDE, RESERPINE
SLO-PHYLLIN GG ................................................................. THEOPHYLLINE, GUAIFENESIN
SLO-PHYLLIN ....................................................... THEOPHYLLINE (NON-SUSTAINED RELEASE)
SSKI. ...................................................................................... POTASSIUM IODIDE
SUDAFED ...............................................................................PSEUDOEPHEDRINE HCl
SYNTHROID .........................................................................LEVOTHYROXINE SODIUM
TENUATE................................................................................ DIETHYLPROPION HCl
TESTOSTERONE
TUINAL ......................................................AMOBARBITAL SODIUM, SECOBARBITAL SODIUM
VASODILAN ..................................................................................... ISOXSUPRINE
105 CMR, § 720.200