Ex Parte Archer et alDownload PDFPatent Trial and Appeal BoardDec 21, 201512264462 (P.T.A.B. Dec. 21, 2015) Copy Citation UNITED STA TES p A TENT AND TRADEMARK OFFICE APPLICATION NO. FILING DATE 12/264,462 11104/2008 26384 7590 12/21/2015 NAVAL RESEARCH LABORATORY AS SOCIA TE COUNSEL (PA TENTS) CODE 1008.2 4555 OVERLOOK A VENUE, S.W. WASHINGTON, DC 20375-5320 FIRST NAMED INVENTOR Marie J. Archer UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O. Box 1450 Alexandria, Virginia 22313-1450 www .uspto.gov ATTORNEY DOCKET NO. CONFIRMATION NO. 99189-USl 1215 EXAMINER CROW, ROBERT THOMAS ART UNIT PAPER NUMBER 1634 MAILDATE DELIVERY MODE 12/21/2015 PAPER Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte MARIE J. ARCHER, BAOCHUAN LIN, and DAVID A. STENGER Appeal2013-004075 1 Application 12/264,462 Technology Center 1600 Before DONALD E. ADAMS, DEMETRA J. MILLS, and FRANCISCO C. PRATS, Administrative Patent Judges. PRATS, Administrative Patent Judge. DECISION ON APPEAL This appeal under 35 U.S.C. § 134(a) involves claims to a method in which target ribonucleic acid is hybridized to an immobilized single- stranded nucleic acid probe. The Examiner rejected the claims for obviousness and obviousness-type double patenting. We have jurisdiction under 35 U.S.C. § 6(b ). We affirm. 1 The Real Party in Interest is the Government of the United States of America, as represented by the Secretary of the Navy. App. Br. 2. Appeal2013-004075 Application 12/264,462 STATEMENT OF THE CASE The Specification discloses "a general method for the selective capture of RNA that can be used for either target enrichment or background subtraction applications." Spec. i-f 14. The method uses a "magnetic bead- based solid phase functionalized with a phosphorous dendrimer linker disclosed in US Patent Application 11/751,096 that allows control of the performance by changing the probe loading capacity." Id. The Specification explains that the "thermal stability of the solid phase allows the method to be performed in a single-step process and recovery of the targets to be performed through heat denaturation which greatly reduced the processing steps involved in performing the experiments." Id. Claims 1-18 stand finally rejected as follows: (1) Claims 1--4, 6, 9, 12-15, and 17, under 35 U.S.C. § 103(a) for obviousness over Van Ness, 2 Yeh, 3 Sampath, 4 and Groebe5 (Final Action 2- 14); (2) Claim 5, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Trevisiol 6 (Final Action 14--15); (3) Claims 7 and 8, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Szasz7 (Final Action 15-18); 2 U.S. Patent Appl. Pub. No. 2003/0077595 Al (published Apr. 24, 2003). 3 U.S. Patent No. 6,238,866 Bl (issued May 29, 2001). 4 U.S. Patent Appl. Pub. No. 2007 /0248969 Al (published Oct. 25, 2007). 5 Duncan R. Groebe and Olke C. Uhlenbeck, Thermal Stability of RNA Hairpins Containing a Four-Membered Loop and a Bulge Nucleotide, 28 BIOCHEMISTRY 742-747 (1989). 6 U.S. Patent Appl. Pub. No. 2005/0214767 Al (published Sept. 29, 2005). 7 U.S. Patent Appl. Pub. No. 2005/0186601 Al (published Aug. 25, 2005). 2 Appeal2013-004075 Application 12/264,462 (4) Claims 9 and 10, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Lockhart8 (Final Action 18-21); (5) Claim 11, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Archer9 (Final Action 21-23); (6) Claim 16, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Denz 10 (Final Action 23-24); (7) Claim 18, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Lesche 11 (Final Action 24--26); (8) Claims 1-3, 5, 6, 11-15, and 17, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath (Final Action 27-28); (9) Claims 4 and 9, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Van Ness (Final Action 28-30); (10) Claim 7, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Szasz (Final Action 31-32); 8 U.S. Patent Appl. Pub. No. 2002/0012940 Al (published Jan. 31, 2002). 9 Marie J. Archer et al., Magnetic bead-based solid phase for selective extraction of genomic DNA, 355 ANAL. BIOCHEM. 285-297 (2006). 1° Christopher R. Denz and Dipak K. Dube, The benefits of 28S rRNAfor standardization of reverse transcription-polymerase chain reaction for studying gene expression, 341 ANAL. BIOCHEM. 382-384 (2005). 11 U.S. Patent Appl. Pub. No. 2009/0298054 Al (filed Dec. 3, 2009). 3 Appeal2013-004075 Application 12/264,462 (11) Claim 8, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Van Ness (Final Action 32-34); (12) Claims 9 and 10, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath, Van Ness, Lockhart, and Groebe (Final Action 34--38); (13) Claim 16, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Denz (Final Action 3 8-39); and (14) Claim 18, provisionally, on the ground ofnonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Lesche (Final Action 39-41 ). Claim 1 illustrates the appealed subject matter and reads as follows: 1. A method comprising: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized by covalent bonding to the dendrimer; contacting the solid surface with a sample suspected or known to contain both a target ribonucleic acid from a target organism and a background ribonucleic acid from a background organism; wherein the target ribonucleic acid 1s complementary to the probe nucleic acid; and wherein the background ribonucleic acid is not complementary to the probe nucleic acid; 4 Appeal2013-004075 Application 12/264,462 App. Br. 10. denaturing the target ribonucleic acid and the background ribonucleic acid at thermal conditions sufficient to denature the target ribonucleic acids and the background ribonucleic acid to produce denatured ribonucleic acids while the sample is in contact with the solid surface; and incubating the sample to allow hybridization of the denatured target ribonucleic acid to the probe nucleic acids. OBVIOUSNESS In rejecting claims 1--4, 6, 9, 12-15, and 17 for obviousness over Van Ness, Yeh, Sampath, and Groebe, the Examiner cited Van Ness as describing a process in which an oligonucleotide probe bound to a solid surface was contacted with a target RNA, as recited in claim 1. Final Action 3. The Examiner found that Van Ness did not expressly describe the target RNA as being denatured, as recited in claim 1, and cited teachings in Van Ness, as well as Groebe, to show that an ordinary artisan would have been prompted to ensure that the target RNA was denatured. Id. at 4--5. The Examiner also cited Yeh as evidence that an ordinary artisan would have considered it obvious to heat and denature the target RNA in Van Ness's process in the presence of the solid support, as recited in claim 1, because doing so "would have resulted in a method having the added advantage of allowing quantitative annealing [of] the [target RNA] analytes to the probes as explicitly taught by Yeh et al (column 11, lines 19-27)." Id. at 6; see also id. at 7 ("the known technique of denaturing target RNA molecules in a sample that is in contact with a solid surface as taught by of 5 Appeal2013-004075 Application 12/264,462 Yeh et al predictably results in a reliable denaturation step allowing reliable hybridization of the target molecules to the immobilized probe molecules"). The Examiner conceded that, although both Van Ness and Yeh taught that the target RNA in their processes was part of a complex mixture of nucleic acid molecules, neither reference expressly taught that the analyte was a first RNA from a target organism, and that there was a second RNA from a background organism in the sample, as required by claim 1. Id. at 7. To address that deficiency, the Examiner cited Sampath as teaching "the known technique of selectively detecting the presence of a first RNA from a first organism in the presence of a second RNA from a second organism." Id. The Examiner reasoned that an ordinary artisan would have considered it obvious in view of Sampath to modify Van Ness's method by using a sample that included RNA from a background organism in addition to RNA from a target organism because doing so "would have resulted in a method having the added advantage of allowing detection data to be cleaned up as explicitly taught by Sampath et al. (paragraph 0387)." Id. at 8. Id. The Examiner additionally reasoned: [I]t would have been obvious to the ordinary artisan that the known technique of detecting the presence of a target RNA nucleic acid in the presence of a second RNA from a background organism as taught by of Sampath et al could have been applied to the method of Van Ness et al in view of Yeh et al with predictable results because the known technique of detecting the presence of a target RNA nucleic acid in the presence of a second RNA from a background organism as taught by of Sampath et al predictably results in a detection of a specific nucleic acid in a complex sample. 6 Appeal2013-004075 Application 12/264,462 As stated in In re Oetiker, 977F.2d1443, 1445 (Fed. Cir. 1992): [T]he examiner bears the initial burden . . . of presenting a prima facie case of unpatentability .... After evidence or argument is submitted by the applicant in response, patentability is determined on the totality of the record, by a preponderance of evidence with due consideration to persuasiveness of argument. We select claim 1 as representative of the claims subject to this ground of rejection. 37 C.F.R. § 41.37(c)(iv). Appellants' arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 1. Appellants contend that the Examiner has not advanced a rationale adequate to support the proposed combination of references, because the references are non-analogous art. App. Br. 3--4. In particular, Appellants contend, although Sampath discloses a sample containing RNA from a target organism as well as RNA from a background organism, Sampath's objective is to perform mass spectrometry on the mixture, "which is not relevant to the methods of the Van Ness and Yeh. The mere existence of the RNA mixture of Sampath does not render obvious the application of the methods of Van Ness and Yeh to that mixture." Id. at 4. Moreover, Appellants contend, "that a mass spectrometry analysis of the mixture was successful in Sampath does not indicate that any other method, including the presently claimed selective hybridization of target species RNA, would be successful with such a mixture." Id. Appellants' arguments do not persuade us that the Examiner erred. Van Ness describes methods of ascertaining the presence of target RNA molecules in a biological sample by hybridizing the RNA from the sample to 7 Appeal2013-004075 Application 12/264,462 immobilized nucleic acids having a sequence complementary to the target RNA, as recited in claim 1. See Van Ness i-f 11. Van Ness explains that its biological sample may be from a number of sources, including not only tissue from living organisms, but also from the environment, for example air, water, or solid samples. Id. at i-f 12. Yeh discloses that its nucleic acid analysis methods may similarly use biological or environmental samples. Yeh, 12:35-38. Sampath, which is also directed to ascertaining the presence of a target nucleic acid in a sample (see Sampath i-f 287), similarly discloses that the samples it analyzes "may include both biological and environmental samples" (id. at i-f 269). As the Examiner noted, Sampath discloses that "nucleic acids from organisms other than those to be detected may be present as background in a test sample." Id. at i-f 271. Given Sampath's disclosure of using the same types of samples as used in Van Ness and Yeh, and given Sampath' s disclosure that such samples contain background nucleic acid from organisms other than the target organism, Appellants do not persuade us that a preponderance of the evidence fails to support the Examiner's conclusion that an ordinary artisan would have considered it obvious that the samples of Van Ness and Yeh would also contain RNA from a background organism that is not the target orgamsm. Appellants also do not persuade us (see App. Br. 4), that Van Ness, Yeh, and Sampath are not in the same field of endeavor as the claimed method. Like the method of claim 1, Van Ness and Yeh both describe methods of ascertaining the presence of target RNA molecules in a biological sample by hybridizing the RNA from the sample to immobilized 8 Appeal2013-004075 Application 12/264,462 nucleic acids having a sequence complementary to the target RNA, as recited in claim 1. See Van Ness i-f 11; Yeh, 11:20-38. While Sampath may use mass spectrometry as a final tool in identifying the target nucleic acid of interest, Sampath, nonetheless, hybridizes known primers to target nucleic acid in its sample to obtain and identify the target nucleic acid by amplification. See Sampath i-f 287 ("Primers are selected to hybridize to conserved sequence regions of nucleic acids derived from a [target] bioagent, and which bracket variable sequence regions to yield a bioagent identifying amplicon, which can be amplified and which is amenable to molecular mass determination.") (emphasis added). Thus, while Sampath may have used the hybridizing reaction between its primers and its target to amplify the target (see Reply Br. 2), Sampath, nonetheless, like Van Ness and Yeh, uses hybridization to ascertain the presence of a target nucleic acid, including RNA, in a tested sample. Accordingly, Appellants do not persuade us that the cited references are not in the same filed of endeavor as the claimed method. We are, therefore, not persuaded that the cited references are non-analogous art. See In re Klein, 647 F.3d 1343, 1348 (Fed. Cir. 2011) (A reference is analogous prior art when it is "from the same field of endeavor, regardless of the problem addressed .... ") (emphasis added). In sum, for the reasons discussed, Appellants' arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 1. Because Appellants do not advance any secondary evidence of nonobviousness, we affirm the Examiner's obviousness rejection of claim 1 over Van Ness, Yeh, 9 Appeal2013-004075 Application 12/264,462 Sampath, and Groebe. Because they were not argued separately, claims 2--4, 12-15, and 17 fall with claim 1. 37 C.F.R. § 41.37(c)(iv). As to claims 6 and 9, Appellants argue that the Examiner erroneously argued that those claims do not recite subtraction of background RNA. Reply Br. 1-2 (citing Ans. 44:12-13). We are not persuaded. In the Final Action, the Examiner explained that Van Ness met claim 6' s separation step by disclosing washing the sample lysate from the solid support (Final Action 11 (citing Van Ness i-f 270)), and claim 9's thermal elution step by disclosing heat denaturation to remove target from the array (id. (citing Van Ness i-f 300)). Appellants do not direct us to any clear or specific evidence suggesting that the Examiner erroneously found that Van Ness teaches the features recited in claims 6 and 9. Accordingly, we also affirm the Examiner's obviousness rejection of claims 6 and 9 over Van Ness, Yeh, Sampath, and Groebe. In rejecting claim 5 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, and Groebe for the teachings discussed above, and cited Trevisiol as evidence that the dendrimer recited in claim 5 would have been obvious to use when immobilizing a nucleic acid probe to a solid support. Final Action 14--15. Appellants contend only that the same arguments discussed above as to the combination of Van Ness, Yeh, Sampath, and Groebe apply to the rejection of claim 5. App. Br. 5. As discussed above, we do not find those arguments persuasive. Accordingly, because Appellants identify no deficiency in the Examiner's obviousness rationale as to claim 5, and because we detect none, we affirm the Examiner's obviousness rejection of that claim. 10 Appeal2013-004075 Application 12/264,462 In rejecting claims 7 and 8 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, and Groebe for the teachings discussed above, and cited Szasz as evidence that the analytical steps recited in claims 7 and 8 would have been obvious additions to the process suggested by the other references. Final Action 15-18. Appellants contend that the same arguments discussed above as to the combination of Van Ness, Yeh, Sampath, and Groebe apply to the rejection of claims 7 and 8. App. Br. 5. As discussed above, we do not find those arguments persuasive. Appellants also contend that the Examiner erroneously argued that claims 7 and 8 do not recite subtraction of background RNA. Reply Br. 1-2 (citing Ans. 44:12-13). Appellants do not direct us, however, to any clear or specific evidence suggesting that the Examiner erroneously found that Szasz teaches the features recited in claims 7 and 8, nor do Appellants explain why the Examiner erred in concluding that an ordinary artisan would have considered it obvious to include the additional steps recited in claims 7 and 8 in the process suggested by the other references. Accordingly, because Appellants identify no deficiency in the Examiner's obviousness rationale as to claims 7 and 8, and because we detect none, we affirm the Examiner's obviousness rejection of those claims. In rejecting claims 9 and 10 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, and Groebe for the teachings discussed above, and cited Lockhart as evidence that the additional steps recited in claims 9 and 10 would have been obvious additions to the process suggested by the other references. Final Action 18-21. 11 Appeal2013-004075 Application 12/264,462 Appellants contend that the same arguments discussed above as to the combination of Van Ness, Yeh, Sampath, and Groebe apply to the rejection of claims 9 and 10. App. Br. 5. As discussed above, we do not find those arguments persuasive. Appellants also contend that the Examiner erroneously argued that claims 9 and 10 do not recite subtraction of background RNA. Reply Br. 1- 2 (citing Ans. 44:12-13). Appellants do not direct us, however, to any clear or specific evidence suggesting that the Examiner erroneously found that Lockhart teaches the features recited in claims 9 and 10, nor do Appellants explain why the Examiner erred in concluding that an ordinary artisan would have considered it obvious to include the additional steps recited in claims 9 and 10 in the process suggested by the other references. Accordingly, because Appellants identify no deficiency in the Examiner's obviousness rationale as to claims 9 and 10, and because we detect none, we affirm the Examiner's obviousness rejection of those claims. In rejecting claim 11 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, and Groebe for the teachings discussed above, and cited Archer as evidence that it would have been obvious to use paramagnetic beads, as recited in claim 11, in the process suggested by the other references. Final Action 21-23. Appellants contend only that the same arguments discussed above as to the combination of Van Ness, Yeh, Sampath, and Groebe apply to the rejection of claim 11. App. Br. 6. As discussed above, we do not find those arguments persuasive. Accordingly, because Appellants identify no deficiency in the Examiner's obviousness rationale as to claim 11, and 12 Appeal2013-004075 Application 12/264,462 because we detect none, we affirm the Examiner's obviousness rejection of that claim. In rejecting claim 16 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, Groebe, for the teachings discussed above, and cited Denz as evidence that it would have been obvious to use probes complementary to the human 18S and 28S RNAs, as recited in claim 16, in the process suggested by the other references. Final Action 23-24. Appellants contend only that the same arguments discussed above as to the combination of Van Ness, Yeh, Sampath, and Groebe apply to the rejection of claim 16. App. Br. 6. As discussed above, we do not find those arguments persuasive. Accordingly, because Appellants identify no deficiency in the Examiner's obviousness rationale as to claim 16, and because we detect none, we affirm the Examiner's obviousness rejection of that claim. In rejecting claim 18 for obviousness, the Examiner relied on Van Ness, Yeh, Sampath, Groebe, for the teachings discussed above, and cited Lesche as evidence that an ordinary artisan would have considered it obvious to apply the process suggested by the other references to a sample in which the amount of background RNA exceeds the amount of target RNA, as recited in claim 18. Final Action 24--26. Appellants argue: [I]n Lesche, the background DNA is from the same organism as the target. Detection is by distinguishing methylated nucleotides from non-methylated nucleotides (0052), which is not performed by hybridization and is unrelated to the methods of the other references. The mere existence of the mixture of 13 Appeal2013-004075 Application 12/264,462 Lesche does not render obvious the application of the methods of Van Ness and Yeh to that mixture. App. Br. 7; see also Reply Br. 2 ("There is no teaching that the fraction upon which hybridization is performed [in Lesche] is a mixture of target and background RNA. Even if it does contain a mixture, the hybridization technique would still not distinguish between normal RNA and tumor RNA."). Appellants' arguments do not persuade us that the Examiner erred. The Examiner cited Lesche as describing "the known technique of detecting trace amounts of a first target nucleic acid in the presence of an excess of background nucleic acid" (Final Action 25), not as disclosing the specific sample or purification technique that might be used in the methods described in Van Ness. As the Examiner found, Lesche discloses that biological samples used in molecular cancer screenings contain small amounts of target DNA in larger amounts of background DNA. Lesche i-f 30 ("Blood based molecular cancer screening assays are faced with the challenge to detect minute amounts of tumor DNA in a background of normal DNA from other tissues."). As the Examiner found also, Lesche used hybridization to assist in its analysis of the RNA obtained from its sample. Id. at i-f 139 ("Detection involves contacting the nucleic acids and in particular the mRNA of the sample with a DNA sequence serving as a probe to form hybrid duplexes."). Given these teachings, Appellants do not persuade us that a preponderance of the evidence fails to support the Examiner's conclusion-- that an ordinary artisan, testing the biological or environmental samples described in Van Ness, Yeh, and Sampath, would have considered it obvious to test a sample in which a target RNA was present in an amount less than 14 Appeal2013-004075 Application 12/264,462 that of the background RNA, as recited in claim 18. That Lesche might have ultimately used methylation as a marker for its RNA of interest (id. at i-f 52), and used purification steps in addition to the hybridization steps used for sequence detection (Reply Br. 2), does not negate Lesche's suggestion that samples of type described in Van Ness, Yeh, and Sampath would have been expected to contain background RNA in amounts in excess of the target RNA. Accordingly, because Appellants' arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case, we affirm the Examiner's obviousness rejection of claim 18. OBVIOUSNESS-TYPE DOUBLE PATENTING As noted above, the Examiner entered seven provisional rejections on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096, in light of various combinations of the Sampath, Van Ness, Szasz, Lockhart, Groebe, Denz, and Lesche references. Final Action 27--41. In response to each rejection, Appellants state only that "[a]s the rejection is provisional, a response will be provided upon allowance of one of the applications." App. Br. 7, 8, 9. Accordingly, we summarily affirm the Examiner's provisional obviousness-type double patenting rejections. See MPEP § 1205.02 (Arguments and evidence not presented in an appeal brief "are waived for purposes of the appeal and the Board may summarily sustain any grounds of rejections not argued.") 15 Appeal2013-004075 Application 12/264,462 SUMMARY For the reasons discussed, we affirm the Examiner's rejection of: (1) Claims 1--4, 6, 9, 12-15, and 17, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, and Groebe; (2) Claim 5, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Trevisiol; (3) Claims 7 and 8, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Szasz; (4) Claims 9 and 10, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Lockhart; (5) Claim 11, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Archer; (6) Claim 16, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Denz; (7) Claim 18, under 35 U.S.C. § 103(a) for obviousness over Van Ness, Yeh, Sampath, Groebe, and Lesche; (8) Claims 1-3, 5, 6, 11-15, and 17, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/7 51,096 in view of Sampath; (9) Claims 4 and 9, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Van Ness; (10) Claim 7, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Szasz; 16 Appeal2013-004075 Application 12/264,462 (11) Claim 8, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Van Ness; (12) Claims 9-10, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath, Van Ness, Lockhart, and Groebe; (13) Claim 16, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Denz; and (14) Claim 18, provisionally, on the ground of nonstatutory obviousness-type double patenting over claims 1-15 of copending Application Serial No. 11/751,096 in view of Sampath and Lesche. No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a). AFFIRMED KRH 17 Copy with citationCopy as parenthetical citation