Cal. Code Regs. tit. 27 § 25705

Current through Register 2024 Notice Reg. No. 43, October 25, 2024

Section 25705 - Specific Regulatory Levels Posing No Significant Risk

(a) Daily exposure to a chemical at a level which does not exceed the level set forth in subsections (b), (c) and (d) for such chemical shall be deemed to pose no significant risk within the meaning of Section 25249.10(c) of the Act.

(b) Levels of exposure deemed to pose no significant risk may be determined by the lead agency based on a risk assessment conducted by the lead agency pursuant to the guidelines set forth in Section 25703, or a risk assessment reviewed by the lead agency and determined to be consistent with the guidelines set forth in Section 25703.

(1) The following levels based on risk assessments conducted or reviewed by the lead agency shall be deemed to pose no significant risk:

	Chemical Name			Level (micrograms/day)
		Acrylonitrile		0.7
		Aldrin		0.04
		Antimony Oxide (Antimony Trioxide)		0.13 (inhalation)
		Arsenic		0.06 (inhalation)
		Asbestos	100 fibers inhaled/day*
		Benz[a]anthracene		0.033 (oral)
		Benzene		6.4 (oral)
				13 (inhalation)
		Benzidine		0.001
		Benzo[b]fluoranthene		0.096 (oral)
		Benzo[j]fluoranthene		0.11 (oral)
		Benzofuran		1.1
		Bis(2-chloroethyl)ether		0.3
		Bis(chloromethyl)ether		0.02
		Bromochloroacetic acid		0.70
		Bromodichloroacetic acid		0.95
		Bromoethane		96
		Bromoform		64
		Butylated hydroxyanisole		4000
		Cadmium		0.05 (inhalation)
		Carbon tetrachloride		5
		N-Carboxymethyl-N-nitrosourea		0.70
		p-Chloroaniline		1.5
		p-chloro-?,?,?-trifluorotoluene		23
		p-Chloroaniline hydrochloride		1.9
		Chloroethane		150
		Chlorothalonil		41
		Chromium (hexavalent compounds)		0.001 (inhalation)
		Chrysene		0.35 (oral)
		C.I. Direct Blue 218		50
		DDT, DDE and DDD (in combination)		2
		7H-Dibenzo[c,g]carbazole		0.0030 (oral)
		Dibenzo[a,h]pyrene		0.0054 (oral)
		Dibenzo[a,i]pyrene		0.0050 (oral)
		1,2-Dibromo-3-chloropropane (DBCP)		0.1
		Dibromoacetic acid		2.8
		Dichloroacetic acid		17
		para-Dichlorobenzene		20
		3,3'-Dichlorobenzidine		0.6
		Dichloromethane (Methylene chloride)		200 (inhalation)
		1,2-Dichloropropane		9.7
		1,3-Dichloropropene		3.7 (oral)
				3.7 (inhalation)
		Dieldrin		0.04
		Di(2-ethylhexyl)phthalate (DEHP)		310
		Diisononyl phthalate (DINP)		146
		3,3'-Dimethoxybenzidine		0.15
		3,3'-Dimethoxybenzidine dihydrochloride		0.19
		3,3'-Dimethylbenzidine		0.044
		3,3'-Dimethylbenzidine dihydrochloride		0.059
		1,4-Dioxane		30
		Epichlorohydrin		9
		Ethylbenzene		54 (inhalation)
				41 (oral)
		Ethylene dibromide		0.2 (ingestion)
				3 (inhalation)
		Ethylene dichloride		10
		Ethylene oxide		2
		Glycidol		0.54
		Glyphosate		1100
		Hexachlorobenzene		0.4
		Hexachlorodibenzodioxin		0.0002
		Hexachlorocyclohexane (technical grade)		0.2
		Lead	15 (oral)
		Lead acetate	23 (oral)
		Lead phosphate	58 (oral)
		Lead subacetate	41 (oral)
		Malathion		180
		2-Methylaziridine (propyleneimine)		0.028
		5-Methylchrysene		0.0084 (oral)
		Methylhydrazine		0.058 (oral)
				0.090 (inhalation)
		Methylhydrazine sulfate		0.18
		4-Methylimidazole		29
		5-Morpholinomethyl-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone		0.18
		MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone)		0.11
		Naphthalene		5.8
		Nitromethane		39
		N-Nitroso-n-dibutylamine		0.06
		N-Nitrosodiethylamine		0.02
		N-Nitrosodimethylamine		0.04
		N-Nitrosodiphenylamine		80
		N-Nitrosodi-n-propylamine		0.1
		N-Nitroso-N-ethylurea		0.03
		N-Nitroso-N-methylurea		0.006
		Phenyl glycidyl ether		5.0
		Phenylhydrazine		1.0
		Phenylhydrazine hydrochloride		1.4
		Polybrominated biphenyls		0.02
		Polygeenan		1200
		Styrene		27
		2,3,7,8-Tetrachlorodibenzo-p-dioxin		0.000005
		Tetranitromethane		0.059
		Toxaphene		0.6
		Trichloroacetic acid		9.9
		Trichloroethylene		14 (oral)
				50 (inhalation)
		2,4,6-Trichlorophenol		10
		2,4,6-Trinitrotoluene		8.2
		Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)		5.4
		Urethane		0.7
		Vinyl chloride		3
		Vinylidene chloride		0.88
		2,6-Xylidine		110
__________

* Fibers equal to or greater than 5 micrometers in length and 0.3 micrometers in width, with a length to width ratio of greater than or equal to 3:1 as measured by phase contrast microscopy.

(c) Unless a specific regulatory level for a chemical known to the state to cause cancer has been established in subsection (b), levels of exposure deemed to pose no significant risk may be determined by the lead agency based on state or federal risk assessments.

(1) Any interested party may request the lead agency to reevaluate a level established in this subsection based on scientific considerations that indicate the need for the lead agency to develop its own risk assessment or to conduct a detailed review of the risk assessment used to derive the level in question. Such request shall be made in writing, and shall include a description of the scientific considerations that indicate the need for the lead agency to develop its own risk assessment or to conduct a detailed review of the risk assessment used to derive the level in question. The lead agency may establish a level for the chemical in question in subsection (b) as it deems necessary.

(2) The following levels based on state or federal risk assessments shall be deemed to pose no significant risk:

	Chemical Name			Level (micrograms/day)
		Acetaldehyde	90 (inhalation)
		Acrylamide	0.2
		Aniline	100
		Azobenzene	6
		Benzo[a]pyrene	0.06
		Benzyl chloride	4
		Beryllium oxide	0.1
		Beryllium sulfate	0.0002
		Bromodichloromethane	5
		1,3-Butadiene	0.4
		Chlordane	0.5
		Chloroform	20 (ingestion)
			40 (inhalation)
		Coke oven emissions	0.3
		DDVP (Dichlorvos)	2
		Dichloromethane (Methylene chloride)	50
		2,4-Dinitrotoluene	2
		Folpet	200
		Formaldehyde (gas)	40
		Furmecyclox	20
		Heptachlor	0.2
		Heptachlor epoxide	0.08
		Hexachlorocyclohexane
		alpha isomer	0.3
		beta isomer	0.5
		gamma isomer	0.6
		Hydrazine	0.04
		Hydrazine sulfate	0.2
		Imazalil	11
		4,4'-Methylene
		bis (N,N-dimethyl)benzeneamine	20
		Nickel refinery dust	0.8
		Nickel subsulfide	0.4
		N-Nitrosodiethanolamine	0.3
		N-Nitrosomethylethylamine	0.03
		N-Nitrosopyrrolidine	0.3
		Pentachlorophenol	40
		Polychlorinated biphenyls (PCBs)	0.09
		Tetrachloroethylene	14

(d) Unless a specific regulatory level has been established for a chemical known to the state to cause cancer in subsection (b) or (c), levels of exposure deemed to pose no significant risk may be determined by the lead agency using an expedited method consistent with the procedures specified in Section 25703.

(1) Any interested party may request the lead agency to reevaluate a level established in this subsection and to consider the adoption, in subsection (c), of a level based on a state or federal risk assessment. Such request shall be made in writing, and shall include a copy of the state or federal risk assessment which the interested party wishes the lead agency to consider as the basis for a level in subsection (c). The lead agency may establish a level in subsection (c) for the chemical in question based on a state or federal risk assessment as it deems necessary.

(2) Any interested party may request the lead agency to reevaluate a level established in this subsection based on scientific considerations that indicate the need for a conventional risk assessment. Such request shall be made in writing, and shall include a description of the scientific considerations that indicate the need for a conventional risk assessment. The lead agency may conduct a conventional risk assessment for the chemical in question, and establish a level in subsection (b) as it deems necessary.

(3) The following levels of exposure based on risk assessments conducted by the lead agency using an expedited method consistent with the procedures specified in Section 25703 shall be deemed to pose no significant risk:

	Chemical Name			Level (micrograms/day)
		A-alpha-C
		(2-Amino-9H-pyridol[2,3-b]indole)	2
		Acetamide	10
		2-Acetylaminofluorene	0.2
		Actinomycin D	0.00008
		AF-2;[2-(2-furyl)-3(5-nitro-2-furyl) acrylamide]	3
		2-Aminoanthraquinone	20
		o-Aminoazotoluene	0.2
		4-Aminobiphenyl (4-aminodiphenyl)	0.03
		3-Amino-9-ethylcarbazole hydrochloride	9
		l-Amino-2-methylanthraquinone	5
		2-Amino-5-(5-nitro-2-furyl) -1,3,4-thiadiazole	0.04
		Amitrole	0.7
		o-Anisidine	5
		o-Anisidine hydrochloride	7
		Aramite	20
		Auramine	0.8
		Azaserine	0.06
		Azathioprine	0.4
		Benzyl violet 4B	30
		beta-Butyrolactone	0.7
		Carbazole	4.1
		Captafol	5
		Captan	300
		Chlorambucil	0.002
		Chlordecone (Kepone)	0.04
		Chlorendic acid	8
		Chlorinated paraffins (Average chain length, C12; approximately 60 percent chlorine by weight)	8
		Chloromethyl methyl ether (technical grade)	0.3
		3-Chloro-2-methylpropene	5
		4-Chloro-ortho-phenylenediamine	40
		p-Chloro-o-toluidine	3
		p-Chloro-o-toluidine hydrochloride	3.3
		Chlorozotocin	0.003
		C. I. Basic Red 9 monohydrochloride	3
		Cinnamyl anthranilate	200
		p-Cresidine	5
		Cupferron	3
		Cyclophosphamide (anhydrous)	1
		Cyclophosphamide (hydrated)	1
		D&C Red No. 9	100
		Dacarbazine	0.01
		Daminozide	40
		Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)	9
		2,4-Diaminoanisole	30
		2,4-Diaminoanisole sulfate	50
		4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline)	5
		2,4-Diaminotoluene	0.2
		Dibenz[a,h]anthracene	0.2
		1,1-Dichloroethane	100
		Diethylstilbestrol	0.002
		Digylcidyl resorcinol ether (DGRE)	0.4
		Dihydrosafrole	20
		4-Dimethylaminoazobenzene	0.2
		trans-2[Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole	2
		7,12-Dimethylbenz(a)anthracene	0.003
		Dimethylcarbamyl chloride	0.05
		1,2-Dimethylhydrazine	0.001
		Dimethylvinylchloride	20
		Direct Black 38 (technical grade)	0.09
		Direct Blue 6 (technical grade)	0.09
		Direct Brown 95 (technical grade)	0.1
		Disperse Blue 1	200
		Estradiol 17B	0.02
		Ethyl-4,4'-dichlorobenzilate (chlorobenzilate)	7
		Ethylene thiourea	20
		Ethyleneimine	0.01
		2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole	0.3
		Glu-P-1 (2-Amino-6-methyldipyrido [1,2-a:3',2'-d]imidazole)	0.1
		Glu-P-2 (2-Aminodipyrido[1,2-a:3', 2'-d]imidazole)	0.5
		Gyromitrin (Acetaldehyde methylformylhydrazone)	0.07
		HC Blue 1	10
		Hexachloroethane	20
		Hydrazobenzene (1,2-Diphenylhydrazine)	0.8
		IQ (2-Amino-3-methylimidazo [4,5-f]quinoline)	0.5
		Isobutyl nitrite	7.4
		Lasiocarpine	0.09
		Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)	0.6
		MeIQ (2-Amino-3,4-dimethylimidazo [4,5-f] quinoline)	0.46
		MeIQx (2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline)	0.41
		Melphalan	0.005
		Methyl carbamate	160
		3-Methylcholanthrene	0.03
		4,4'-Methylene bis(2-chloroaniline)	0.5
		4,4'-Methylene bis(2-methylaniline)	0.8
		4,4'-Methylenedianiline	0.4
		4,4'-Methylenedianiline dihydrochloride	0.6
		Methyl methanesulfonate	7
		2-Methyl-1-nitroanthraquinone (of uncertain purity)	0.2
		N-Methyl-N'-nitro-N-nitrosoguanidine	0.08
		Methylthiouracil	2
		Michler's ketone	0.8
		Mirex	0.04
		Mitomycin C	0.00009
		Monocrotaline	0.07
		Nalidixic acid	28
		2-Naphthylamine	0.4
		Nitrilotriacetic acid	100
		Nitrilotriacetic acid, trisodium salt monohydrate	70
		5-Nitroacenaphthene	6
		Nitrofen (technical grade)	9
		Nitrofurazone	0.5
		1-[(5-Nitrofurfurylidine)-amino]-2-imidazolidinone	0.4
		N-[4-(5-Nitro-2-furyl)-2-thiazolyl] acetamide	0.5
		p-Nitrosodiphenylamine	30
		4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone	0.014
		N-Nitroso-N-methylurethane	0.006
		N-Nitrosomorpholine	0.1
		N-Nitrosonornicotine	0.5
		N-Nitrosopiperidine	0.07
		Phenacetin	300
		Phenazopyridine	4
		Phenazopyridine hydrochloride	5
		Phenesterin	0.005
		Phenobarbital	2
		Phenoxybenzamine	0.2
		Phenoxybenzamine hydrochloride	0.3
		o-Phenylenediamine	26
		o-Phenylenediamine dihydrochloride	44
		o-Phenylphenate, sodium	200
		Ponceau MX (D&C Red No. 5)	200
		Ponceau 3R (FD&C Red No. 1)	40
		Potassium bromate	1
		Procarbazine	0.05
		Procarbazine hydrochloride	0.06
		1,3-Propane sultone	0.3
		beta-Propiolactone	0.05
		Propylthiouracil	0.7
		Reserpine	0.06
		Safrole	3
		Sterigmatocystin	0.02
		Streptozotocin	0.006
		Styrene oxide	4
		Sulfallate	4
		1,1,2,2-Tetrachloroethane	3
		Thioacetamide	0.1
		4,4'-Thiodianiline	0.05
		Thiourea	10
		Toluene diisocyanate	20
		o-Toluidine	4
		o-Toluidine hydrochloride	5
		Trimethyl phosphate	24
		Tris(1-aziridinyl)phosphine sulfide (Thiotepa)	0.06
		Tris(2,3-dibromopropyl)phosphate	0.3
		Trp-P-1 (Tryptophan-P-1)	0.03
		Trp-P-2 (Tryptophan-P-2)	0.2
		Vinyl trichloride (1,1,2-Trichloroethane)	10

Cal. Code Regs. Tit. 27, § 25705

Note: Authority cited: Section 25249.12, Health and Safety Code. Reference: Sections 25249.5, 25249.6, 25249.9, 25249.10, 25249.11 and 57004, Health and Safety Code.

1. New section filed 2-24-88 as an emergency; operative 2-27-88 (Register 88, No. 11). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-27-88.
2. New section refiled 6-27-88 as an emergency; operative 6-27-88 (Register 88, No. 27). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 10-25-88.
3. New section refiled 10-17-88 as an emergency; operative 10-25-88 (Register 88, No. 44). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 2-22-89.
4. New section refiled 2-21-89 as an emergency; operative 2-22-89 (Register 89, No. 10). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-22-89.
5. Certificate of Compliance including amendment transmitted to OAL 6-9-89 and filed 7-10-89 (Register 89, No. 30).
6. New subsection (b) filed 12-1-89; operative 12-31-89 (Register 89, No. 49).
7. Amendment of subsection (b) filed 5-16-90; operative 6-15-90 (Register 90, No. 25).
8. Amendment of subsection (b) filed 5-24-90; operative 6-23-90 (Register 90, No. 25).
9. Editorial correction of printing error in subsection (b) submitted to OAL for printing only 10-9-90 (Register 91, No. 3).
10. Amendment of subsection (b) adding Benzene filed 11-26-90; operative 12-26-90 (Register 91, No. 3).
11. Amendment of subsection (b) adding Arsenic, Butylated hydroxyanisole, Cadmium, and Chromium filed 9-16-92; operative 10-16-92 (Register 92, No. 38).
12. Amendment of subsection (b) adding Hexachlorodibenzodioxin and 2,3,7,8-Tetrachlorodibenzo-p-dioxin filed 9-16-92; operative 10-16-92 (Register 92, No. 38).
13. Amendment of subsection (b) adding dichloromethane, trichloroethylene and vinyl chloride filed 9-24-92; operative 10-26-92 (Register 92, No. 39).
14. Amendment of subsection (a), new subsections (b)-(b)(1), renumbering of subsection (c) to (b)(2) and amendment, new subsections (c)-(d)(3) filed 10-9-92; operative 11-9-92 (Register 92, No. 41).
15. Effective 10-29-99, allyl chloride and chlorodibromomethane were removed from the list of chemicals known to the State to cause cancer. The no significant risk levels of these chemicals were also removed, effective 10-29-99, from Title 22, CCR, sections 12705(c)(2) and 12705(d)(3) (Register 2001, No. 19).
16. Amendment of subsections (b), (c)(2) and (d)(3) filed 7-18-2002; operative 8-17-2002 (Register 2002, No. 29).
17. Amendment of subsections (a) and (b)(2) and deletion of extraneous subsection (b) designator filed 1-7-2003; operative 2-6-2003 (Register 2003, No. 2).
18. Amendment of subsections (b)(1) and (d)(3) filed 2-25-2003; operative 3-27-2003 (Register 2003, No. 9).
19. Amendment of subsection (b)(1) filed 4-12-2004; operative 5-12-2004 (Register 2004, No. 16).
20. Amendment of subsection (b)(1) filed 6-10-2004; operative 7-10-2004 (Register 2004, No. 24).
21. Amendment of subsection (b)(1) adding "1,2-Dichloropropane" filed 12-23-2004; operative 1-22-2005 (Register 2004, No. 52).
22. Amendment of subsections (b)(1) and (d)(3) filed 8-12-2005; operative 9-11-2005 (Register 2005, No. 32).
23. Change without regulatory effect amending subsection (d)(3) filed 1-30-2007 pursuant to section 100, title 1, California Code of Regulations (Register 2007, No. 5).
24. Effective December 8, 2006, 5 nitro-o-anisidine was removed from the list of chemicals known to cause cancer. This resulted in 5 nitro-o-anisidine and its no significant risk level contained in Section 12705(d)(3) no longer being applicable effective December 8, 2006. This change without regulatory effect removing 5 nitro-o-anisidine from Section 12705(d)(3) was filed 1-30-2007 pursuant to section 100, title 1, California Code of Regulations (Register 2007, No. 5).
25. Amendment of subsection (b)(1) adding "Nitromethane" filed 3-27-2008; operative 4-26-2008 (Register 2008, No. 13).
26. Change without regulatory effect renumbering title 22, section 12705 to title 27, section 25705, including amendment of subsections (b), (d) and (d)(3), filed 6-18-2008 pursuant to section 100, title 1, California Code of Regulations (Register 2008, No. 25).
27. Amendment of subsection (b)(1) filed 8-8-2008; operative 9-7-2008 (Register 2008, No. 32).
28. Amendment of subsection (b)(1) filed 4-7-2009; operative 5-7-2009 (Register 2009, No. 15).
29. Amendment of subsection (b)(1) filed 7-13-2010; operative 8-12-2010 (Register 2010, No. 29).
30. Amendment of subsection (b)(1) filed 1-26-2011; operative 2-25-2011 (Register 2011, No. 4).
31. Amendment of subsection (b)(1) filed 1-26-2011; operative 2-25-2011 (Register 2011, No. 4).
32. Amendment of subsection (b)(1) filed 1-9-2012; operative 2-8-2012 (Register 2012, No. 2).
33. Amendment of subsections (b)(1) and (d)(3) filed 3-15-2012; operative 6-15-2012 pursuant to Government Code section 11343.4(b) (Register 2012, No. 11).
34. Amendment of subsection (c)(2) filed 3-26-2012; operative 4-25-2012 (Register 2012, No. 13).
35. Amendment of subsection (b)(1) filed 6-18-2012; operative 7-18-2012 (Register 2012, No. 25).
36. Repealer of subsection (b)(2) and amendment of Note filed 7-12-2012; operative 8-11-2012 (Register 2012, No. 28).
37. Amendment of subsection (b)(1) adding Tris(1,3-dichloro-2-propyl) phosphate and amendment of Note filed 9-20-2012; operative 10-20-2012 (Register 2012, No. 38).
38. Editorial correction repealing subsection (b)(2) pursuant to 7-12-2012 filing (Register 2012, No. 39).
39. Amendment of subsection (b)(1) adding "Bromoethane" filed 12-17-2012; operative 1-16-2013 (Register 2012, No. 51).
40. Amendment of subsection (b)(1) adding "Diisononyl phthalate (DINP)" filed 2-8-2016; operative 4/1/2016 (Register 2016, No. 7).
41. Amendment of subsection (b)(1) adding "Styrene" filed 5-4-2017; operative 7/1/2017 (Register 2017, No. 18).
42. Amendment of subsection (b)(1) adding "Malathion" filed 2-5-2018; operative 4/1/2018 (Register 2018, No. 6).
43. Amendment of subsection (b)(1) adding "Glyphosate" filed 4-6-2018; operative 7/1/2018 (Register 2018, No. 14).
44. Amendment of subsection (b)(1) adding "Vinylidene chloride" filed 5-9-2018; operative 7-1-2018 (Register 2018, No. 19).
45. Amendment of subsection (b)(1) adding "Bromochloroacetic acid" filed 2-5-2019; operative 4-1-2019 (Register 2019, No. 6).
46. Amendment of subsection (b)(1) adding "Bromodichloroacetic acid" filed 2-5-2019; operative 4/1/2019 (Register 2019, No. 6).
47. Amendment of subsection (b)(1) filed 12-2-2020; operative 4/1/2021 (Register 2020, No. 49).
48. Amendment of subsection (b)(1) adding "Dichloroacetic acid" filed 6-24-2021; operative 10/1/2021 (Register 2021, No. 26).
49. Amendment of subsection (b)(1) adding "Trichloroacetic acid" filed 7-6-2021; operative 10-1-2021 (Register 2021, No. 28). Filing deadline specified in Government Code section 11349.3(a) extended 60 calendar days pursuant to Executive Order N-40-20.
50. Amendment of subsection (b)(1) adding "Dibromoacetic acid" filed 7-6-2021; operative 10/1/2021 (Register 2021, No. 28). Filing deadline specified in Government Code section 11349.3(a) extended 60 calendar days pursuant to Executive Order N-40-20.
51. Amendment of subsection (b)(1) adding "1,3-Dichloropropene" filed 6-13-2022; operative 10/1/2022 (Register 2022, No. 24).
52. Amendment of subsection (b)(1) adding "Antimony Oxide (Antimony Trioxide)" filed 10-3-2023; operative 1/1/2024 (Register 2023, No. 40).