On June 22, 2023, DEA published a final rule regarding the timing with which registrants are required to report the theft or loss of controlled substances (the “Final Rule”). 88 FR 40707. DEA’s regulations have always required registrants to notify their local DEA Field Division Office, in writing, of any theft or significant loss of controlled substances within one (1) business day of the discovery of the theft or loss, but DEA’s regulations have been silent as to when registrants must follow-up on this initial written notice with the subsequent submission of a DEA Form 106. Through the Final Rule, DEA has amended its regulations to now require DEA Forms 106 to be submitted within 45 calendar days after discovery of the theft or loss. Note that DEA’s original proposed rule suggested a 15-day reporting deadline; however, the Final Rule landed on a 45-day deadline after DEA considered the industry’s comments regarding the need for sufficient time to first “complete an accurate and thorough investigation” before submitting a Form 106.Additionally, while DEA’s regulations have historically been silent as to the method by which DEA Forms 106 are to be submitted (e.g. by m